รศ. ดร. เต็มดวง  ลิ้มไพบูลย์ คุณวุฒิ : • วท.บ. ( เทคนิคการแพทย์) (เกียรตินิยมอันดับ 1) • วท.ม. ( ชีวเคมี) • ปริญญาเอก ( ชีวเคมี) E-mail : temduang@kku.ac.th ตำแหน่งทางวิชาการ : รองศาสตราจารย์ ระดับ 9 Research interest : Oncogenes and tumor suppressor genes in various cancers. Microsatellelite instability and loss of heterozygosity in  cholangiocarcinoma Cancer epigenetics Stem cells and Tumor biology Publication : Sriraksa R, Chaopatchayakul P, Jearanaikoon P, Leelayuwat C, Limpaiboon T. Verification of complete bisulfite modification using Calponin-specific primer sets. Clin Biochem 2009 Nov 13 (Epub ahead of print) Chaopatchayakul P, Jearanaikoon P, Yuenyao P, Limpaiboon T.  Aberrant methylation of apoptotic signaling genes in response and non-response cervical carcinoma. Am J Obstet Gynecol. (in press). Thanasai J, Limpaiboon T, Jearanaikoon P, Sripa B, Pairojkul C, Tantimavanich S, Miwa M. Effect of thymidine phosphorylase on tumor aggressiveness and 5-Fluorouracil sensitivity in cholangiocarcinoma. World J Gastroenterol (in press). Khaenam P, Jearanaikoon P, Pairojkul C, Bhudisawasdi V, Limpaiboon T. genetic and epigenetic alterations of RIZ1 and the correlation to clinicopathological parameters in liver fluke-related cholangiocarcinoma. Experimental and Therapeutic Medicine (in press). Wanram S, Limpaiboon T, Leelayuwat C, Yuenyao P, Guiney DG, Lulitanond V, Jearanaikoon P. The use of viral load as a surrogate marker in predicting disease progression for patients with early invasive cervical cancer with integrated human papillomavirus type 16. Am J Obstet Gynecol. 2009; 201(1):79.e1-7. Chinnasri P, Pairojkul C, Jearanaikoon P, Sripa B, Bhudhisawasdi V, Tantimavanich S, Limpaiboon T. Preferentially different mechanisms of inactivation of 9p21 gene cluster in liver fluke-related cholangiocarcinoma. Hum Pathol. 2009;40(6):817-26. Muenphon K, Limpaiboon T, Jearanaikoon P, Pairojkul C, Sripa B, Bhudhisawasdi V. Amplification of chromosome 21q22.3 harboring trefoil factor family genes in liver fluke related cholangiocarcinoma is associated with poor prognosis. World J Gastroenterol 2006; 12(26):4143-4148. Thanasai J, Limpaiboon T, Jearanaikoon P, Bhudhisawasdi V, Khuntikeo N, Sripa B, Miwa M. Amplification of D22S283 as a favorable prognostic indicator in liver fluke related cholangiocarcinoma. World J Gastroenterol 2006; 12(27): 4338-4344. Limpaiboon T, Tapdara S, Jearanaikoon P, Sripa B, Bhudhisawasdi V. Prognostic significance of microsatellite alterations at 1p36 in cholangiocarcinoma. World J Gastroenterol 2006; 12(27): 4377-4382. Chomvarin C, Tishyadhigama P, Siripornmongcolchai T, Wongwanich S,           Limpaiboon T, Chaicumpar K  Analysis of three phenotyping methods and pulsed-   field gel electrophoresis for differentiation of methicillin resistant Staphylococcus aureus isolated from two hospitals in Thailand.  Southeast Asian J Trop Med Public             Health. 2005; 36(5): 1221-8. Kanjanavirojkul N, Limpaiboon T, Patarapadungkit N, Yuenyao P, Pairojkul C. Chromosome 3p alterations in northeastern Thai women with cervical carcinoma. Asian Pac J Cancer Prev. 2005 Oct-Dec;6(4):501-4.   Limpaiboon T, Khaenam P, Chinnasri P, Soonklang M, Jearanaikoon P, Sripa B, Pairojkul C, Bhudhisawasdi V.  Promoter hypermethylation is a major event of hMLH1 gene inactivation in liver fluke related cholangiocarcinoma.  Cancer Lett.          2005; 20;217(2):213-9. Chomvarin C, Siripornmongcolchai T, Chaicumpar K, Limpaiboon T, Wongkham C, Yutanawiboonchai W.  Evaluation of polymerase chain reaction, conventional and      MRSA screen latex agglutination methods for detection of methicillin-resistant, -borderline and -susceptible Staphylococcus aureus. Southeast Asian J Trop Med Public Health. 2004; 35(4):879-85. Limpaiboon T, Sripa B, Wongkham S, Bhudhisawasdi V, Chau-in S, Teerajetgul Y.   Anti-p53 antibodies and p53 protein expression in cholangiocarcinoma. Hepatogastroenterology. 2004 Jan-Feb;51(55):25-8. Siripornmongcolchai T, Chomvarin C, Chaicumpar K, Limpaiboon T, Wongkhum C.  Evaluation of different primers for detecting mecA gene by PCR in comparison with phenotypic methods for discrimination of methicillin-resistant Staphylococcus aureus.  Southeast Asian J Trop Med Public Health. 2002 Dec;33(4):758-63. Limpaiboon T, Krissadarak K, Sripa B, Jearanaikoon P, Bhuhisawasdi V, Chau-in S, Romphruk A, Pairojkul C. Microsatellite alterations in liver fluke related cholangiocarcinoma are associated with poor prognosis.  Cancer Lett. 2002 Jul                 26;181(2):215-22. Limpaiboon T, Pooart J, Bhattarakosol P, Niruthisard S, Chantratita W, Lulitanond           V. p53 status and human papillomavirus infection in Thai women with cervical carcinoma. Southeast Asian J Trop Med Public Health. 2000 Mar;31(1):66-71. Pooart J, Limpaiboon T, Lulitanond V. Improved nonisotopic PCR-SSCP for screening of p53 mutations.  Clin Biochem. 1999 Apr;32(3):233-5. Leelayuwat C, Srisuk T, Paechaiyaphum R, Limpaiboon T, Romphruk A, Romphruk A. Production and evaluation of Taq DNA polymerase.  J Med Assoc Thai. 1997 Sep;80 Suppl 1:S129-37. Honore N, Bergh S, Chanteau S, Doucet-Populaire F, Eiglmeier K, Garnier T, Georges C, Launois P, Limpaiboon T, Newton S, et al. Nucleotide sequence of the first cosmid from the Mycobacterium leprae genome project: structure and function of the Rif-Str regions.  Mol Microbiol. 1993 Jan;7(2):207-14. Saul A, Cooper J, Hauquitz D, Irving D, Cheng Q, Stowers A, Limpaiboon T. The            42-kilodalton rhoptry-associated protein of Plasmodium falciparum. Mol Biochem Parasitol. 1992 Jan;50(1):139-49. Limpaiboon T, Shirley MW, Kemp DJ, Saul A. 7H8/6, a multicopy DNA probe for distinguishing isolates of Plasmodium falciparum. Mol Biochem Parasitol. 1991 Aug;47(2):197-206. Limpaiboon T, Taylor DW, Jones G, Geysen HM, Saul A. Characterization of a Plasmodium falciparum epitope recognized by a monoclonal antibody with broad       isolate and species specificity.  Southeast Asian J Trop Med Public Health. 1991 Jun;22(2):284. Limpaiboon T, Taylor DW, Jones G, Geysen HM, Saul A. Characterization of a Plasmodium falciparum epitope recognized by a monoclonal antibody with broad       isolate and species specificity.  Southeast Asian J Trop Med Public Health. 1990 Sep;21(3):388-96. Erratum in: Southeast Asian J Trop Med Public Health. 1991 Jun;22(2):284. Yuthavong Y, Limpaiboon T. The relationship of phosphorylation of membrane proteins with the osmotic fragility and filterability of Plasmodium berghei-infected mouse erythrocytes.  Biochim Biophys Acta. 1987 Jul 29;929(3):278-87.